Various stresses such as pests, diseases, bad soil temperature or humidity conditions. can impair seeds germination and seedlings emergence. To cope with the problem, an usual practice is to control soil-borne pathogens by conventional fungicides, but this raises concerns for human health, biodiversity and the environment. A better understanding of these stresses and their interactions is essential to develop durable and sustainable pest management strategies. Agronomists Lamichhane et al. review key knowledge gaps in the field and propose five research priorities to better manage damping-off diseases.