Heat stress lowers wheat growth and productivity. Agronomists Akter and Islam review some appropriate strategies able to improve wheat yield under extreme heat stress. These include the choice of cultivars, the management of soil moisture and nutrients, the adjustment of planting time and the use of exogenous protectants. It remains, however, that the overall success of the complex wheat heat stress management will depend on the prospective collaboration of crop modelers, molecular biologists, and plant physiologists.